A MID file may also contain song data used by various guitar rhythm video games, such as Guitar Hero, Clone Hero, Phase Shift, and Rock Band. It does not contain audio data, but instead uses MIDI data to mark events during song playback. Events include guitar notes, practice mode sections, star power phrases, and other events.

MID files are typically stored in a folder with one or more audio files. For example, a Guitar Hero audio track (saved as an .OGG file) may have a corresponding MID file that contains guitar notes to be played for that song. Most guitar rhythm gamers will not need to open or edit MID files unless they are looking to modify notes or create their own song files. If you want to modify notes, you can open and edit MID files using FeedBack and Moonscraper Chart Editor. You can import MID files directly into Guitar Hero III using Guitar Hero Three Control Panel (GHTPC). NOTE: Guitar rhythm files are also saved with a .CHART file extension to avoid confusion with standard MIDI files.