A GLOX file is a graphics file used by Microsoft Office productivity applications for conveying information and ideas in presentations, charts, and documents. It contains the layout and styles for a graphic and includes placeholders for inserting text. GLOX files use Open XML formatting, which is the same format used for .DOCX, .XLSX, and .PPTX files.

While GLOX files are used by Microsoft Office, they cannot be directly opened using the File → Open... menu. Instead, the SmartArt graphics can be accessed from the SmartArt tool, which is available in Office 2007 and later applications. Custom SmartArt graphics can be downloaded from the Microsoft Office Online website. They are downloaded as .CAB files which each contain a GLOX file. GLOX files must be placed in the "SmartArt Graphics" folder in order to be accessed by Microsoft Office. The directory differs depending on the operating system, but is similar to the following path in the application data folder: \Microsoft\Templates\SmartArt Graphics\